Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 6/20 | 0.50 |
| ▸ | CCKAR | P32238 | 5/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667987 | 0.89 | HTR2B (0.51) | CCKBRCCKARTP53 | |
| SCHEMBL8669391 | 0.82 | PDE4D (0.47) | CCKBRCCKARTP53 | |
| SCHEMBL8801152 | 0.81 | FNTA (0.56) | CCKBRCCKARHDAC3HDAC1HDAC6 | |
| SCHEMBL8669226 | 0.81 | CCKBR (0.50) | CCKBRCCKARTP53 | |
| SCHEMBL8667933 | 0.79 | CCKBR (0.62) | CCKBRCCKARSCN9A | |
| SCHEMBL8669189 | 0.78 | CCKBR (0.58) | CCKBRCCKARHDAC3HDAC1HDAC6 | |
| SCHEMBL12893392 | 0.76 | TP53 (0.65) | CCKBRCCKARHDAC3HDAC1HDAC6 | |
| SCHEMBL9865396 | 0.74 | GABRP (0.62) | CCKBRCCKARHDAC3HDAC1HDAC6 | |
| SCHEMBL2687533 | 0.74 | GABRP (0.62) | CCKBRCCKARHDAC3HDAC1HDAC6 | |
| SCHEMBL30320115 | 0.74 | GABRP (0.62) | CCKBRCCKARHDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843941-A | Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5532359-A | FUNGICIDES | GENENTECH, INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |