Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 7/20 | 0.58 |
| ▸ | CCKAR | P32238 | 5/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667990 | 0.89 | CCKBR (0.55) | CCKBRCCKAR | |
| SCHEMBL8667933 | 0.86 | CCKBR (0.62) | CCKBRCCKARSCN9A | |
| SCHEMBL8801155 | 0.82 | FNTA (0.51) | CCKBRCCKARHDAC3HDAC1HDAC8 | |
| SCHEMBL8803196 | 0.82 | CCKBR (0.47) | CCKBRCCKAR | |
| SCHEMBL8669229 | 0.81 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL8585550 | 0.79 | CCKBR (0.71) | CCKBRCCKARSCN9A | |
| SCHEMBL8585545 | 0.79 | CCKBR (0.71) | CCKBRCCKARSCN9A | |
| SCHEMBL8669186 | 0.78 | CCKBR (0.50) | CCKBRCCKARHDAC3HDAC1HDAC8 | |
| SCHEMBL12893392 | 0.76 | TP53 (0.65) | CCKBRCCKARHDAC3HDAC1HDAC8 | |
| SCHEMBL8939417 | 0.74 | SENP1 (0.79) | CCKBRCCKARSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843941-A | Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5532359-A | FUNGICIDES | GENENTECH, INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |