Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.50 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.50 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10591562 | 0.88 | ESR1 (0.58) | ESR1MAPTLMNAPGRCYP2C9 | |
| SCHEMBL1171043 | 0.85 | ESR1 (0.65) | ESR1MAPTLMNAPGRCYP2C9 | |
| SCHEMBL74326 | 0.85 | ESR1 (0.65) | ESR1MAPTLMNAPGRCYP2C9 | |
| Hydroquinone SCHEMBL28097256 | 0.85 | ESR1 (0.65) | ESR1MAPTLMNAPGRCYP2C9 | |
| SCHEMBL31712136 | 0.84 | ESR1 (0.54) | ESR1MAPTLMNAPGRCYP2C9 | |
| Fumaric Acid SCHEMBL7738495 | 0.84 | HCAR2 (0.53) | MAPTLMNAALDH1A1KMT2ACYP3A4 | |
| SCHEMBL28544659 | 0.83 | ESR1 (0.62) | ESR1MAPTLMNAPGRCYP2C9 | |
| Propane SCHEMBL28264453 | 0.83 | ESR1 (0.62) | ESR1MAPTLMNAPGRCYP2C9 | |
| Benzene SCHEMBL28219933 | 0.83 | ESR1 (0.62) | ESR1MAPTLMNAPGRCYP2C9 | |
| Terephthalic Acid SCHEMBL8675145 | 0.81 | DRD1 (0.61) | ESR1MAPTLMNAPGRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5795693-A | Carrier for electrophotography, two component-type developer and image forming method | CANON KABUSHIKI KAISHA (JP) | 1998-08-18 | — | — | US | disclosed |
| US-5143809-A | Polyesters from bisphenol type diol, dicarboxylic acid and tricarboxylic acid | KONICA CORPORATION (JP) | 1992-09-01 | — | — | US | disclosed |
| US-5098922-A | Anticonvulsants | CIBA-GEIGY CORPORATION (US) | 1992-03-24 | — | — | US | disclosed |
| US-5045556-A | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |