Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | DRD4 | P21917 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091429 | 0.77 | BCHE (0.56) | DRD2DRD4DRD3HTR2AHTR1A | |
| SCHEMBL8791508 | 0.77 | SIGMAR1 (0.44) | DRD2DRD4DRD3SIGMAR1HTR1A | |
| SCHEMBL1388159 | 0.76 | DRD4 (0.66) | DRD2DRD4DRD3SIGMAR1HTT | |
| Hydrochloric Acid SCHEMBL8543107 | 0.75 | DRD4 (0.65) | DRD2DRD4DRD3SIGMAR1HTR1A | |
| SCHEMBL15004308 | 0.74 | GRM5 (0.44) | DRD2DRD4DRD3GRM5NPC1 | |
| SCHEMBL12798134 | 0.74 | SIGMAR1 (0.55) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL1388024 | 0.73 | DRD4 (0.57) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL12550622 | 0.73 | SIGMAR1 (0.46) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL8830945 | 0.72 | SIGMAR1 (0.53) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL2395932 | 0.72 | DRD4 (0.67) | DRD2DRD4DRD3SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880512-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028141-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |
| US-5576336-A | Indole derivatives as dopamine D4 antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| WO-1994021627-A1 | INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |