Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 8/20 | 0.42 |
| ▸ | DRD4 | P21917 | 8/20 | 0.42 |
| ▸ | DRD3 | P35462 | 8/20 | 0.42 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387366 | 0.91 | HTR1A (0.44) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL8669389 | 0.77 | DRD2 (0.46) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9091429 | 0.77 | BCHE (0.56) | HTR1ADRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL8858342 | 0.74 | DRD2 (0.48) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL8858344 | 0.74 | DRD2 (0.48) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL1388024 | 0.73 | DRD4 (0.57) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL8858363 | 0.71 | DRD2 (0.37) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL8858360 | 0.71 | DRD2 (0.37) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL1750627 | 0.71 | SIGMAR1 (0.58) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8858358 | 0.71 | HTR1A (0.38) | HTR1ADRD2DRD4DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665722-A | Benzofuran derivatives as D4 receptor antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| EP-0757686-A1 | BENZOFURAN DERIVATIVES AS D 4? RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029911-A1 | BENZOFURAN DERIVATIVES AS D4 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-09 | — | — | WO | disclosed |