Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18813884 | 0.88 | TRPM8 (0.58) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL14223540 | 0.84 | KMT2A (0.60) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL866593 | 0.84 | KMT2A (0.60) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6416999 | 0.77 | KMT2A (0.56) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL17520545 | 0.77 | KMT2A (0.61) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL19138994 | 0.77 | KMT2A (0.61) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL17520458 | 0.76 | KMT2A (0.67) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL19248407 | 0.76 | KMT2A (0.67) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL34472268 | 0.76 | KMT2A (0.67) | TRPM8KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL18676293 | 0.76 | KMT2A (0.67) | TRPM8KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422242-B2 | Phosphodiesterase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-08-23 | — | — | US | disclosed |
| US-9169247-B2 | Tetrahydro-beta-carboline derivatives, synthesis and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2015-10-27 | — | — | US | disclosed |
| US-20150080394-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | COLUMBIA UNIVERSITY (US) | 2015-03-19 | — | — | US | disclosed |
| US-8697875-B2 | Phosphodiesterase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-04-15 | — | — | US | disclosed |
| US-20120309781-A1 | TETRAHYDRO-beta-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2012-12-06 | — | — | US | disclosed |
| US-20120076732-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-03-29 | — | — | US | disclosed |
| US-20110086923-A1 | Method to increase oxygen in male and female sexual organs through the topical use of perfluorocarbons | TENAX THERAPEUTICS, INC | 2011-04-14 | — | — | US | disclosed |
| US-20060134767-A1 | Mitotic kinesin binding site | MERCK & CO., INC. | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309781-A1 | TETRAHYDRO-beta-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF | PDE5A, PDE3A, PDE3B | TRPM8 4726/4885KMT2A 1883/4885MEN1 623/4885 |
| US-20110086923-A1 | Method to increase oxygen in male and female sexual organs through the topical use of perfluorocarbons | SHBG, ACOX3, PAOX | TRPM8 2762/4885KMT2A 4265/4885MEN1 4580/4885 |
| US-20120076732-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE7A, PDE5A, PDE4A | TRPM8 3098/4885KMT2A 3277/4885MEN1 1930/4885 |
| US-20150080394-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE7A, PDE5A, PDE4A | TRPM8 3098/4885KMT2A 3277/4885MEN1 1930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.