Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 5/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.72 |
| ▸ | PGR | P06401 | 3/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14946255 | 0.87 | LMNA (0.79) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL8672115 | 0.87 | NR3C1 (0.72) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL13653728 | 0.86 | HIF1A (0.73) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12434538 | 0.86 | LMNA (0.85) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL8671619 | 0.86 | LMNA (0.85) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL15233739 | 0.85 | LMNA (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| Triamcinolone Acetonide Phosphoric Acid SCHEMBL8856248 | 0.85 | HIF1A (0.79) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL13985471 | 0.85 | LMNA (0.81) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12396729 | 0.84 | LMNA (0.86) | HIF1ALMNACYP3A4NR3C1PGR | |
| Triamcinolone Acetonide Phosphoric Acid SCHEMBL6544867 | 0.84 | HIF1A (0.78) | HIF1ALMNACYP3A4NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5801165-A | Antiinflammatory, immunosuppressive and antialleric 16, 17-alkylidioxy-steroids | RHONE-POULENC RORER LIMITED (GB) | 1998-09-01 | — | — | US | disclosed |
| EP-0675897-B1 | NEW STEROIDS | RHONE POULENC RORER LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| EP-0675897-A1 | NEW STEROIDS. | RHONE POULENC RORER LTD (GB) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994014834-A1 | NEW STEROIDS | RHONE-POULENC RORER LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |