Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Triamcinolone Acetonide Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 5/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.78 |
| ▸ | LMNA | P02545 | 5/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.78 |
| ▸ | PGR | P06401 | 4/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | CNR1 | P21554 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | AR | P10275 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triamcinolone Acetonide Phosphoric Acid SCHEMBL8856248 | 0.93 | HIF1A (0.79) | HIF1ALMNACYP3A4NR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL561411 | 0.91 | HIF1A (0.91) | HIF1ALMNACYP3A4NR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL1869303 | 0.90 | HIF1A (0.89) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL13985471 | 0.90 | LMNA (0.81) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL14114135 | 0.90 | LMNA (0.83) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL13524485 | 0.90 | LMNA (0.83) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL14884636 | 0.89 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL11422147 | 0.89 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL124165 | 0.89 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL15975096 | 0.89 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954323-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING A MIXTURE OF AUTOCROSS-LINKED HYALURONIC ACID AND NONAUTOCROSS-LINKED HYALURONIC ACID AND THEIR USE FOR THE TREATMENT OF ARTHROPATHIES | FIDIA SPA (IT) | 2004-01-07 | — | — | EP | disclosed |
| US-6251876-B1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ARTHROPATHIES COMPRISING AUTOCROSSLINKED HYALURONIC ACID, NONCROSSLINKED HYALURONIC ACID, PHARMACEUTICALLY ACCEPTABLE EXCIPIENT, DILUENT OR CARRIER | FIDIA, S.P.A. (IT) | 2001-06-26 | — | — | US | disclosed |
| EP-0954323-A1 | AUTOCROSS-LINKED HYALURONIC ACID AND RELATED PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ARTHROPATHIES | FIDIA S.p.A. (IT) | 1999-11-10 | — | — | EP | disclosed |
| WO-1997049412-A1 | AUTOCROSS-LINKED HYALURONIC ACID AND RELATED PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ARTHROPATHIES | FIDIA S.P.A. (IT) | 1997-12-31 | — | — | WO | disclosed |