Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.94 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL4955321 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL4955314 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL18062511 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL18062510 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL5422407 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28067914 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29822171 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL32661377 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29349552 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL2774 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707144-B | Chiral quinoline amine compound and preparation method and application thereof | 浙江大学 | 2020-11-24 | — | — | CN | claimed |
| CN-108350466-A | Methods and compositions for determining pH | 芝加哥大学 | 2018-07-31 | — | — | CN | claimed |
| CN-103772445-B | A kind of 1,1 '-ferrocene perfluoroalkyl phosphine nitrogen ligand, its preparation method and application | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-01 | — | — | CN | claimed |
| CN-101293961-A | Electrochromic polymeric compounds, preparing method and application thereof | UNIV ZHEJIANG TECHNOLOGY (CN) | 2008-10-29 | — | — | CN | claimed |
| WO-2005047402-A1 | METHOD OF CORROSION PREVENTION AND ANTICORROSION MATERIAL | TRIGENEX TECHNOLOGIES, INC. (US) | 2005-05-26 | — | — | WO | claimed |
| US-20250188339-A1 | RED SAND DUNES SILICON NANOPARTICLES FOR GREEN ENHANCED OIL RECOVERY | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-06-12 | — | — | US | disclosed |
| US-12139665-B1 | Rheological gradient-based method of recovering oil from hydrocarbon-bearing subterranean geologic formation | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-11-12 | — | — | US | disclosed |
| US-12110453-B2 | Acid injection and fracturing method for porous subterranean geological formation | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-10-08 | — | — | US | disclosed |
| US-12110454-B2 | Downhole rock treatment method with corrosion inhibition | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-10-08 | — | — | US | disclosed |
| US-12104119-B2 | Calcareous rock stimulation method | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-10-01 | — | — | US | disclosed |
| US-20240279534-A1 | ACID INJECTION AND FRACTURING METHOD FOR POROUS SUBTERRANEAN GEOLOGICAL FORMATION | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-08-22 | — | — | US | disclosed |
| US-20240279535-A1 | CALCAREOUS ROCK STIMULATION METHOD | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-08-22 | — | — | US | disclosed |
| CN-85107531-A | Process for producing vinyl chloride polymer | — | 1987-01-21 | — | — | CN | disclosed |
| EP-0158922-A2 | Tetrahydrofuran-2-ylmethylamines | BAYER AG (DE) | 1985-10-23 | — | — | EP | disclosed |
| EP-0153908-A1 | Process for the preparation of pyridine-2,3-dicarboxylic acid | CIBA-GEIGY AG (CH) | 1985-09-04 | — | — | EP | disclosed |
| EP-0034126-A1 | Cosmetic and dermatological compositions for shaving the skin | Maggesi, Luigi (IT) | 1981-08-19 | — | — | EP | disclosed |
| US-4256639-A | Process for the synthesis of isatin derivatives | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO (IT) | 1981-03-17 | — | — | US | disclosed |
| US-4067934-A | FIREPROOFING NYLON AND POLYESTERS | MONSANTO COMPANY (US) | 1978-01-10 | — | — | US | disclosed |
| US-3993623-A | Polymers made flame retardant with condensation products of phosphine oxides | MONSANTO COMPANY (US) | 1976-11-23 | — | — | US | disclosed |
| US-3956301-A | Process for bromination of pyrimidine | ELI LILLY AND COMPANY (US) | 1976-05-11 | — | — | US | disclosed |