Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.94 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL867374 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL4955314 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL18062511 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL18062510 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL5422407 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28067914 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29822171 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL32661377 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29349552 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL2774 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108430988-A | Dihydro-isoquinoline bis derivative is used to handle purposes, composition and the implementation of keratin material | 欧莱雅 | 2018-08-21 | — | — | CN | claimed |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | KOSAK KENNETH M | 2008-02-28 | — | — | US | claimed |
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | KOSAK KENNETH M | 2007-03-15 | — | — | US | claimed |
| CN-1796371-A | Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof | OREAL (FR) | 2006-07-05 | — | — | CN | claimed |
| US-12606830-B2 | Protected antibody-drug and aptamer-drug conjugates | KOSAK KENNETH MICHAEL (US) | 2026-04-21 | — | — | US | disclosed |
| US-20240301480-A1 | METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACIDS AND NUCLEASES IN A BODY FLUID AS INDICATORS OF DISEASE | ARNA GENOMICS US INCORPORATED | 2024-09-12 | — | — | US | disclosed |
| US-20230357868-A1 | COMPOSITIONS AND METHODS FOR OBTAINING PLANT CULTIVARS WITH DESIRED TERPENE PROFILES BASED ON TERPENE SYNTHASE GENE SELECTION | FRONT RANGE BIOSCIENCES INC (US) | 2023-11-09 | — | — | US | disclosed |
| WO-2023086970-A2 | METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACIDS AND NUCLEASES IN A BODY FLUID AS INDICATORS OF DISEASE | ARNA GENOMICS US INCORPORATED (US) | 2023-05-19 | — | — | WO | disclosed |
| US-20210198671-A1 | PROTECTED ANTIBODY-DRUG AND APTAMER-DRUG CONJUGATES | KOSAK KENNETH MICHAEL (US) | 2021-07-01 | — | — | US | disclosed |
| CN-1910153-B | Derivatives of pyridine and quinoline | CONSEJO SUPERIOR INVESTIGACION | 2010-05-26 | — | — | CN | disclosed |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | KOSAK KENNETH M | 2008-02-28 | — | — | US | disclosed |
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | KOSAK KENNETH M | 2007-03-15 | — | — | US | disclosed |
| CN-1910153-A | Derivatives of pyridine and quinoline | CONSEJO SUPERIOR INVESTIGACION (ES) | 2007-02-07 | — | — | CN | disclosed |
| CN-85105798-A | Octahydro- azoles is the preparation method of [4,5-g] quinoline also | — | 1987-01-28 | — | — | CN | disclosed |
| CN-85101547-A | The preparation method and its usage of novel octahydro thiazole [4,5-g] and quinoline compound | — | 1987-01-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | CHMP4B, CTSA, CLTA | ALDH1A1 4767/4885NPC1 101/4885POLB 3940/4885 |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | CHMP4B, CTSA, CLTA | ALDH1A1 4743/4885NPC1 139/4885POLB 3830/4885 |
| US-20210198671-A1 | PROTECTED ANTIBODY-DRUG AND APTAMER-DRUG CONJUGATES | ZFR, APP, RBM26 | ALDH1A1 1853/4885NPC1 1183/4885POLB 914/4885 |
| US-12606830-B2 | Protected antibody-drug and aptamer-drug conjugates | PABPC1, PABPC4, ABCG2 | ALDH1A1 705/4885NPC1 1642/4885POLB 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.