Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | LTA4H | P09960 | 14/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639515 | 0.89 | LTA4H (0.49) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8637317 | 0.82 | MBTPS1 (0.49) | SLC6A2SLC6A4SLC6A3LTA4HCYP1A2 | |
| SCHEMBL2352220 | 0.80 | NPC1 (0.49) | MEN1ALDH1A1KMT2A | |
| SCHEMBL8638832 | 0.80 | SMN1; SMN2 (0.48) | SLC6A2SLC6A4SLC6A3LTA4HHRH1 | |
| SCHEMBL8637391 | 0.77 | LTA4H (0.49) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL619150 | 0.76 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL22797899 | 0.75 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL8639520 | 0.74 | HRH1 (0.47) | SLC6A2SLC6A4SLC6A3CYP2D6HRH1 | |
| SCHEMBL8773746 | 0.73 | LTA4H (0.54) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8637335 | 0.73 | LTA4H (0.56) | LTA4HHRH1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |