Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 16/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637391 | 0.84 | LTA4H (0.49) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8639515 | 0.78 | LTA4H (0.49) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8637317 | 0.74 | MBTPS1 (0.49) | LTA4HHRH1 | |
| SCHEMBL8637335 | 0.74 | LTA4H (0.56) | LTA4HHRH1ITGB3ITGA2BKDM4E | |
| SCHEMBL8674658 | 0.73 | SLC6A2 (0.54) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8639322 | 0.73 | SMN1; SMN2 (0.62) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8635989 | 0.72 | SMN1; SMN2 (0.57) | LTA4HHRH1ITGB3ITGA2BKDM4E | |
| SCHEMBL24322921 | 0.71 | LTA4H (1.00) | LTA4H | |
| SCHEMBL8640865 | 0.70 | HRH1 (0.50) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8644228 | 0.70 | LTA4H (0.52) | LTA4HHRH1ITGB3ITGA2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |