SCHEMBL8675207

SCHEMBL8675207

CCOC(=O)C(Cl)(Cl)C(=O)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 2/20 0.50
NPC1 O15118 2/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
POLB P06746 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
ALDH1A1 P00352 3/20 0.46
MAPT P10636 2/20 0.46
SRC P12931 1/20 0.46
RECQL P46063 1/20 0.44
MMP8 P22894 1/20 0.44
LMNA P02545 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
TSHR P16473 1/20 0.43
CES1 P23141 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
GAA P10253 2/20 0.42
RAB9A P51151 1/20 0.42
ATM Q13315 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9437333 0.84 MEN1 (0.51) PIN1NPC1MEN1KMT2APOLB
SCHEMBL11170973 0.83 POLB (0.55) PIN1NPC1MEN1KMT2APOLB
SCHEMBL9437357 0.82 PIN1 (0.53) PIN1NPC1MEN1KMT2APOLB
SCHEMBL27913593 0.82 SMN1; SMN2 (0.55) KMT2AALDH1A1MAPTLMNATDP1
SCHEMBL8679766 0.81 PIN1 (0.51) PIN1NPC1MEN1KMT2APOLB
SCHEMBL4621876 0.81 PIN1 (0.51) PIN1NPC1MEN1KMT2APOLB
SCHEMBL28458817 0.81 SRC (0.66) PIN1NPC1MEN1KMT2APOLB
SCHEMBL6065169 0.80 SRC (0.65) NPC1MEN1KMT2APOLBALDH1A1
SCHEMBL29029673 0.79 PIN1 (0.50) PIN1NPC1MEN1KMT2APOLB
SCHEMBL5856279 0.79 POLB (0.54) PIN1NPC1MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5728911-A CATALYTIC SOLUTION COPOLYMERIZATION OF ETHYLENE WITH POLYUNSATURATED MONOMER DSM COPOLYMER, INC. (US) 1998-03-17 US disclosed
EP-0705284-B1 PROCESS FOR THE PREPARATION OF LOW MOLECULAR WEIGHT COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE DSM NV (NL) 1997-07-09 EP disclosed
EP-0705284-A1 PROCESS FOR THE PREPARATION OF LOW MOLECULAR WEIGHT COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE DSM NV (NL) 1996-04-10 EP disclosed
WO-1995000564-A1 PROCESS FOR THE PREPARATION OF LOW MOLECULAR WEIGHT COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE DSM N.V. (NL) 1995-01-05 WO disclosed
EP-0044119-B1 PROCESS FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE STAMICARBON B.V. (NL) 1985-05-29 EP disclosed
US-4435552-A COORDINATION CATALYST CONTAINING HALOACYL COMPOUND STAMICARBON B.V. (NL) 1984-03-06 US disclosed
EP-0044119-A2 Process for the preparation of copolymers of ethylene with at least one other 1-alkene STAMICARBON B.V. (NL) 1982-01-20 EP disclosed