Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115208 | 0.78 | — | — | |
| SCHEMBL5974856 | 0.78 | — | — | |
| SCHEMBL2572564 | 0.78 | — | — | |
| SCHEMBL3065380 | 0.78 | — | — | |
| SCHEMBL7172373 | 0.78 | — | — | |
| SCHEMBL3733125 | 0.76 | — | — | |
| SCHEMBL29782812 | 0.76 | — | — | |
| SCHEMBL17082 | 0.76 | — | — | |
| Tromethamine SCHEMBL6803764 | 0.74 | MEN1 (0.43) | MEN1LMNAKMT2A | |
| SCHEMBL6050879 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840816-A | Method of manufacturing a polysiloxane charge transporting material | DOW CORNING TORAY SILICONE CO., LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0771809-A1 | Method of manufacturing a polysiloxane charge transporting material | DOW CORNING ASIA, Ltd. (JP) | 1997-05-07 | — | — | EP | disclosed |