Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48840 | 0.75 | — | — | |
| Tromethamine SCHEMBL8675370 | 0.74 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL21111803 | 0.74 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| SCHEMBL28379184 | 0.73 | — | — | |
| Tromethamine SCHEMBL342628 | 0.72 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| SCHEMBL28724838 | 0.72 | — | — | |
| Tromethamine SCHEMBL845321 | 0.72 | MEN1 (0.53) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL442155 | 0.71 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2021309 | 0.70 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL4927868 | 0.68 | MEN1 (0.42) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472208-A1 | NOVEL 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONE DERIVATIVES, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2004-11-03 | — | — | EP | disclosed |
| US-6794378-B2 | ANTIINFLAMMATORY AGENTS | AJINOMOTO CO., INC. (JP) | 2004-09-21 | — | — | US | disclosed |
| WO-2003066561-A1 | NOVEL 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONE DERIVATIVES, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2003-08-14 | — | — | WO | disclosed |
| EP-0050849-B1 | 4,5-UNSATURATED PROSTANOIC ACID DERIVATIVES | G.D. Searle & Co. (US) | 1984-01-11 | — | — | EP | disclosed |
| EP-0050849-A1 | 4,5-Unsaturated prostanoic acid derivatives | G.D. Searle & Co. (US) | 1982-05-05 | — | — | EP | disclosed |
| US-4322543-A | 4,5-Unsaturated prostanoic acid derivatives | G. D. SEARLE & CO. (US) | 1982-03-30 | — | — | US | disclosed |