Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.55 |
| ▸ | PRKACA | P17612 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.55 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 4/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959044 | 1.00 | MKNK2 (0.55) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL4960002 | 0.84 | CHRNB2 (0.70) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL4056295 | 0.84 | MKNK2 (0.55) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL4064436 | 0.81 | CHRNB2 (0.74) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL3838406 | 0.78 | CHRNB2 (0.53) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL6559282 | 0.76 | CHRNB2 (0.38) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL365733 | 0.76 | ROCK2 (0.50) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL3960211 | 0.76 | ROCK2 (0.50) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL4066057 | 0.76 | ROCK2 (0.47) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL3017873 | 0.75 | CHRNB2 (0.53) | MKNK2ROCK2MAP4K4PRKACAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811442-A | ADMINISTERING ARYL SUBSTITUTED OLEFINIC AMINE COMPOUND IN AN AMOUNT SUFFICIENT TO SELECTIVELY BIND TO AND AFFECT NICOTINIC CHOLINERGIC RECEPTOR SUBTYPES CONTAINING BETA2 SUBUNITS | TARGACEPT, INC. | 1998-09-22 | — | — | US | disclosed |