Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18789612 | 0.73 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1PLA2G1B | |
| SCHEMBL12445275 | 0.72 | MAPT (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1PLA2G1B | |
| SCHEMBL7622508 | 0.69 | PDE4B (0.40) | ALDH1A1L3MBTL1MAPTKDM4ETDP1 | |
| SCHEMBL3420316 | 0.68 | ALDH1A1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1PLA2G1B | |
| SCHEMBL22351864 | 0.68 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1PLA2G1B | |
| SCHEMBL31322264 | 0.67 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1PLA2G1B | |
| SCHEMBL7249419 | 0.67 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1TDP1S1PR1TSHR | |
| SCHEMBL9696405 | 0.66 | CA2 (0.38) | ALDH1A1TDP1TSHR | |
| Anthraquinone SCHEMBL29222026 | 0.65 | ADORA2A (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1PLA2G1B | |
| SCHEMBL50547 | 0.65 | ADORA2A (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707559-A | PROVIDING A STABLE 1,2-DIOXETANE WHICH FORMS INTERMEDIATE UNSTABLE COMPOUNDS WHEN TRIGGERED TO REMOVE BLOCKING GROUPS BY ACTIVATING AGENT SO THAT UNSTABLE COMPOUND DECOMPOSES TO FORM LIGHT AND TWO CARBONYL COMPOUNDS | TROPIX, INC. (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0595369-B1 | Alkene compounds | TROPIX INC (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5386017-A | Can be converted to stable aryl substituted 1,2-dioxetanes which decompose when activated to produce light and carbonyl compounds | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0254051-B1 | Chemiluminescent 1,2-dioxetane compounds | UNIV WAYNE STATE (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0595369-A1 | Alkene compounds | TROPIX, INC. (US) | 1994-05-04 | — | — | EP | disclosed |
| US-4962192-A | Chemiluminescent 1,2-dioxetane compounds | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1990-10-09 | — | — | US | disclosed |
| US-4857652-A | Chemiluminescent 1,2-dioxetane compounds | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0254051-A2 | Chemiluminescent 1,2-dioxetane compounds | THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1988-01-27 | — | — | EP | disclosed |