Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | MMP1 | P03956 | 5/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | MMP7 | P09237 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351711 | 0.73 | KCNA5 (0.53) | KEAP1NFE2L2KCNA5CXCR3PTGES | |
| SCHEMBL8015046 | 0.71 | KCNA5 (0.56) | KEAP1NFE2L2KCNA5PTGESTAS2R14 | |
| SCHEMBL7419400 | 0.71 | KCNA5 (0.48) | KEAP1NFE2L2KCNA5CXCR3PTGES | |
| SCHEMBL8601705 | 0.70 | MMP13 (0.49) | KEAP1NFE2L2CXCR3PTGESTAS2R14 | |
| SCHEMBL8601707 | 0.70 | MMP13 (0.49) | KEAP1NFE2L2CXCR3PTGESTAS2R14 | |
| SCHEMBL7423956 | 0.70 | KCNA5 (0.49) | KEAP1NFE2L2KCNA5CXCR3PTGES | |
| SCHEMBL7350312 | 0.70 | TAS2R14 (0.48) | KEAP1NFE2L2KCNA5CXCR3PTGES | |
| SCHEMBL7350978 | 0.70 | KCNA5 (0.54) | KEAP1NFE2L2KCNA5CXCR3PTGES | |
| SCHEMBL7350309 | 0.70 | TAS2R14 (0.48) | KEAP1NFE2L2KCNA5CXCR3PTGES | |
| SCHEMBL7350974 | 0.70 | TAS2R14 (0.48) | KEAP1NFE2L2KCNA5CXCR3PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770624-A | INHIBITORS OF TUMOR NECROSIS FACTOR ALPHA AND MATRIX DEGRADING METALLOPROTEINEASE ACTIVITY | NOVARTIS CORP. (US) | 1998-06-23 | — | — | US | disclosed |