Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRD2 | P25440 | 2/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.42 |
| ▸ | CCKBR | P32239 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.39 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670555 | 0.93 | LMNA (0.44) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8674323 | 0.90 | LMNA (0.42) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8667949 | 0.89 | NOTCH1 (0.42) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8670541 | 0.89 | OPRK1 (0.41) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8674206 | 0.87 | LMNA (0.40) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8674482 | 0.86 | LMNA (0.44) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8676259 | 0.86 | CCKBR (0.43) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8676158 | 0.85 | HTR2B (0.40) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8674518 | 0.84 | CCKBR (0.40) | BRD4BRD2BRD3CCKBRLMNA | |
| SCHEMBL8674054 | 0.84 | PDE3A (0.41) | BRD4BRD2BRD3CCKBRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843941-A | Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1998-12-01 | — | — | US | disclosed |