Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8677002 | 0.99 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL8678035 | 0.97 | PPARG (0.41) | PDE4APDE4BPDE4CPDE4DNR1H4 | |
| SCHEMBL8679823 | 0.94 | PPARA (0.40) | NPC1RAB9AMEN1KMT2APPARG | |
| SCHEMBL8678800 | 0.85 | CXCR2 (0.45) | PDE4APDE4BPDE4CPDE4DSCN5A | |
| SCHEMBL8676570 | 0.84 | SENP7 (0.42) | NPC1RAB9AKMT2AHDAC1PPARG | |
| SCHEMBL8677000 | 0.84 | CXCR2 (0.44) | PDE4APDE4BPDE4CPDE4DCXCR2 | |
| SCHEMBL8679799 | 0.82 | MAPT (0.42) | NPC1RAB9AKMT2AHDAC1PPARG | |
| SCHEMBL8676393 | 0.81 | MRGPRX4 (0.47) | NR1H4HDAC1SMN1; SMN2 | |
| SCHEMBL8678032 | 0.81 | CXCR2 (0.44) | PDE4APDE4BPDE4CPDE4DCXCR2 | |
| SCHEMBL8679540 | 0.80 | PTGER1 (0.44) | NPC1RAB9AMEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753641-A | SYNERGISTIC THERAPY COMPRISING FINASTERIDE AND TERAZOSIN DRUGS | MERCK & CO., INC. (US) | 1998-05-19 | — | — | US | disclosed |