Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 6/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5604749 | 0.81 | APP (0.47) | ESR1ESR2CYP3A4ALOX15HIF1A | |
| SCHEMBL21741209 | 0.80 | CYP1A2 (0.54) | CYP1A2TTRESR1ESR2CYP3A4 | |
| SCHEMBL8679613 | 0.79 | ABCB11 (0.45) | CYP1A2TSHRTDP1APPCYP2D6 | |
| SCHEMBL21967023 | 0.78 | CYP1A2 (0.52) | CYP1A2TTRESR1ESR2CYP3A4 | |
| SCHEMBL3216361 | 0.78 | APP (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL22750625 | 0.77 | CYP1A2 (0.52) | CYP1A2TTRESR1ESR2CYP3A4 | |
| SCHEMBL29946581 | 0.77 | CYP1A2 (0.52) | CYP1A2TTRESR1ESR2CYP3A4 | |
| SCHEMBL8517544 | 0.73 | ALDH1A1 (0.41) | CYP3A4ALOX15TSHRTDP1GABRA1 | |
| SCHEMBL2473384 | 0.73 | CYP1A2 (0.42) | CYP1A2TTRESR1ESR2CYP3A4 | |
| SCHEMBL21836123 | 0.72 | ASIC3 (0.57) | CYP1A2ESR1ESR2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998024747-A1 | A PROCESS FOR THE PREPARATION OF NABUMETONE | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1998-06-11 | — | — | WO | claimed |
| WO-1998024747-A1 | A PROCESS FOR THE PREPARATION OF NABUMETONE | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1998-06-11 | — | — | WO | disclosed |