Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.66 |
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.63 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.63 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.63 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | THPO | P40225 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849117 | 1.00 | MAPT (0.66) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10759532 | 0.88 | MAPT (0.58) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10626040 | 0.88 | CYP1A2 (0.61) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8680780 | 0.87 | ADORA3 (0.67) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10661614 | 0.87 | CYP3A4 (0.57) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9501269 | 0.87 | HIF1A (0.76) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27286151 | 0.86 | MAPT (0.55) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11004460 | 0.86 | CYP1A2 (0.59) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL26036353 | 0.85 | ADORA3 (0.73) | MAPTADORA3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3905675 | 0.84 | ADORA3 (0.83) | MAPTADORA3CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | claimed |
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | IAPP, PNLIP, GPR119 | MAPT 2817/4885ADORA3 2848/4885CYP1A2 4857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.