Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorzoxazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.68 |
| ▸ | NOS1 | P29475 | 3/20 | 0.68 |
| ▸ | NOS2 | P35228 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | THPO | P40225 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorzoxazone SCHEMBL29720120 | 0.82 | NOS1 (1.00) | NOS3NOS1NOS2LMNACYP1A2 | |
| Chlorzoxazone SCHEMBL35178 | 0.82 | NOS1 (1.00) | NOS3NOS1NOS2LMNACYP1A2 | |
| Chlorzoxazone SCHEMBL35177 | 0.82 | KDM4E (0.70) | LMNACYP1A2NPSR1KDM4EPSMB8 | |
| Chlorzoxazone SCHEMBL27696905 | 0.79 | KDM4E (0.66) | LMNACYP1A2NPSR1KDM4EPSMB8 | |
| Chlorzoxazone SCHEMBL8681418 | 0.74 | KDM4E (0.63) | LMNACYP1A2NPSR1KDM4EPSMB8 | |
| Zoxazolamine SCHEMBL10840280 | 0.74 | LMNA (0.81) | LMNACYP1A2NPSR1KDM4EPSMB8 | |
| Chlorzoxazone SCHEMBL16937427 | 0.71 | KDM4E (0.56) | LMNACYP1A2NPSR1KDM4EPSMB8 | |
| SCHEMBL7464328 | 0.71 | KDM4E (0.64) | LMNACYP1A2NPSR1KDM4EPSMB8 | |
| SCHEMBL14920284 | 0.71 | NOS3 (0.65) | NOS3NOS1NOS2LMNACYP1A2 | |
| SCHEMBL7471035 | 0.70 | KDM4E (0.57) | LMNACYP1A2NPSR1KDM4EPSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5729266-A | Recording sheets containing oxazole, isooxazole, oxazolidinone, oxazoline salt, morpholine, thiazole, thiazolidine, thiadiazole and phenothiazine compounds | XEROX CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | disclosed |