Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 13/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684065 | 0.88 | RAB9A (0.47) | MAPK1MAPK3ALDH1A1KDM4EHTT | |
| SCHEMBL8682718 | 0.72 | MAPK1 (0.44) | MAPK1MAPK3MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL4898881 | 0.71 | MAP2K4 (0.50) | MAPK1MAP2K4MAPKAPK3MAPK6HCAR3 | |
| SCHEMBL29690554 | 0.71 | MAP2K4 (0.45) | MAPK1MAP2K4MAPKAPK3MAPK6HCAR3 | |
| SCHEMBL7416496 | 0.71 | TTK (0.40) | MAPK1MAPK3MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL8682542 | 0.71 | TTK (0.35) | MAPK1MAP2K4MAPKAPK3MAPK6JAK2 | |
| SCHEMBL2861172 | 0.70 | LRRK2 (0.61) | MAPK1MAPK3MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL2866791 | 0.67 | MAP2K4 (0.69) | MAPK1MAPK3MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL1144846 | 0.66 | MAP2K4 (0.50) | MAPK1MAP2K4MAPKAPK3MAPK6JAK2 | |
| SCHEMBL27623663 | 0.66 | KDR (0.58) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |