Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8682282 | 0.91 | KDM4E (0.40) | TTKMAPK8MAPK1JAK2MEN1 | |
| SCHEMBL8682545 | 0.75 | F2 (0.37) | HAO1MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL8682713 | 0.71 | MAPK1 (0.42) | MAPK1MAP2K4MAPKAPK3MAPK6JAK2 | |
| SCHEMBL8682283 | 0.68 | KDM4E (0.40) | MAPK1MEN1KMT2APOLB | |
| SCHEMBL2715883 | 0.68 | POLB (0.42) | MEN1KMT2APOLB | |
| SCHEMBL7229706 | 0.68 | POLB (0.42) | MEN1KMT2APOLB | |
| SCHEMBL2861172 | 0.66 | LRRK2 (0.61) | MAPK1MAP2K4MAPKAPK3MAPK6JAK2 | |
| SCHEMBL6178638 | 0.66 | LMNA (0.36) | MEN1KMT2APOLB | |
| SCHEMBL4898881 | 0.66 | MAP2K4 (0.50) | MAPK1MAP2K4MAPKAPK3MAPK6JAK2 | |
| SCHEMBL7250534 | 0.65 | POLB (0.46) | MEN1KMT2APOLBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |