Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684069 | 0.86 | RAB9A (0.46) | MAPK1MAPK3 | |
| SCHEMBL16607505 | 0.75 | ALDH1A1 (0.53) | KDM4DITGB3ITGAVHCAR3CYP1A2 | |
| SCHEMBL4958032 | 0.75 | CSNK2A2 (0.43) | KDM4DCSNK2A2CSNK2BCSNK2A1ITGB3 | |
| SCHEMBL1144988 | 0.72 | KDM4E (0.50) | MAPK1JAK2JAK1MAP2K4MAPKAPK3 | |
| SCHEMBL6753577 | 0.72 | MAP2K4 (0.43) | MAPK1MAPK3CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7982819 | 0.72 | ITGB3 (0.60) | ITGB3ITGAV | |
| SCHEMBL8682713 | 0.72 | MAPK1 (0.42) | MAPK1MAPK3HCAR3JAK2JAK1 | |
| SCHEMBL8682545 | 0.71 | F2 (0.37) | MAPK1MAPK3MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL2861172 | 0.70 | LRRK2 (0.61) | MAPK1MAPK3JAK2JAK1MAP2K4 | |
| SCHEMBL15172582 | 0.70 | MAP2K4 (0.47) | MAPK1MAPK3JAK2JAK1MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |