Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.46 |
| ▸ | RRM2 | P31350 | 3/20 | 0.45 |
| ▸ | RRM1 | P23921 | 1/20 | 0.45 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683080 | 0.74 | RRM2 (0.50) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL8684404 | 0.71 | RRM2 (0.57) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL1882892 | 0.71 | RRM2 (0.61) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL1882894 | 0.71 | RRM2 (0.61) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL29569419 | 0.71 | RRM2 (0.61) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL8689525 | 0.67 | LMNA (0.45) | RRM2MEN1KMT2ANSD2TDP1 | |
| SCHEMBL29773651 | 0.66 | NCOA3 (0.71) | NCOA3NCOA1RRM2RRM1RRM2B | |
| SCHEMBL21519563 | 0.65 | POLB (0.59) | TDP1L3MBTL1ALDH1A1MAPTGAA | |
| SCHEMBL15045214 | 0.65 | FFAR4 (0.74) | MEN1KMT2AALDH1A1MAPTEDNRA | |
| SCHEMBL29227848 | 0.63 | KMT2A (0.55) | MEN1KMT2AL3MBTL1SLC40A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721259-A | Method of using 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0570294-B1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | UNIV YALE (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5281715-A | 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0570294-A1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | YALE UNIVERSITY (US) | 1993-11-18 | — | — | EP | disclosed |