Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RRM2 | P31350 | 8/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6264240 | 0.79 | RRM2 (0.55) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL6264236 | 0.79 | RRM2 (0.55) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL4380310 | 0.79 | RRM2 (0.55) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL4390542 | 0.76 | RRM2 (0.52) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL31753303 | 0.76 | RRM2 (0.52) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL8685653 | 0.75 | MAPT (0.64) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL8683501 | 0.75 | RRM2 (0.48) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL8683429 | 0.74 | RRM2 (0.47) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL3086822 | 0.73 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL31555906 | 0.72 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721259-A | Method of using 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0570294-B1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | UNIV YALE (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5281715-A | 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0570294-A1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | YALE UNIVERSITY (US) | 1993-11-18 | — | — | EP | disclosed |