Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.54 |
| ▸ | ITGA5 | P08648 | 7/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | ITGAV | P06756 | 10/20 | 0.52 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.48 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490295 | 0.86 | GAA (0.60) | GAARAB9AITGB1ITGA5ITGB3 | |
| SCHEMBL7490286 | 0.86 | GAA (0.60) | GAARAB9AITGB1ITGA5ITGB3 | |
| SCHEMBL14270723 | 0.78 | ITGB1 (0.78) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL7494247 | 0.77 | ITGB3 (0.69) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL7494281 | 0.77 | ITGB3 (0.69) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL7490231 | 0.77 | GAA (0.58) | GAARAB9AITGB3ITGA2B | |
| SCHEMBL6093237 | 0.77 | GAA (0.64) | GAARAB9A | |
| Hydrochloric Acid SCHEMBL7482009 | 0.76 | ITGB3 (0.67) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| Hydrochloric Acid SCHEMBL7482028 | 0.76 | ITGB3 (0.67) | ITGB1ITGA5ITGB3ITGA2BITGAV | |
| SCHEMBL22604665 | 0.76 | GAA (0.91) | GAARAB9AITGB3ITGA2BPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |