SCHEMBL868507

SCHEMBL868507

C1=CCC(C2CCCCCC2)CC1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
ALOX15 P16050 2/20 0.36
HSD17B10 Q99714 1/20 0.36
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KDM4E B2RXH2 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1133217 1.00 ALDH1A1 (0.42) ALDH1A1ALOX15HSD17B10LMNATP53
SCHEMBL2001108 0.97 ALDH1A1 (0.44) ALDH1A1ALOX15HSD17B10LMNATP53
SCHEMBL14759977 0.97 ALDH1A1 (0.44) ALDH1A1ALOX15HSD17B10LMNATP53
SCHEMBL29847413 0.92 ALDH1A1 (0.37) ALDH1A1ALOX15HSD17B10LMNATP53
SCHEMBL8463890 0.86 ALDH1A1 (0.44) ALDH1A1ALOX15
SCHEMBL1524920 0.86
SCHEMBL6155112 0.86 ALDH1A1 (0.47) ALDH1A1HSD17B10KDM4E
SCHEMBL122871 0.86 ALDH1A1 (0.47) ALDH1A1HSD17B10KDM4E
SCHEMBL5693055 0.86 ALDH1A1 (0.43) ALDH1A1ALOX15HSD17B10LMNATP53
SCHEMBL596635 0.86 ALDH1A1 (0.43) ALDH1A1ALOX15HSD17B10LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113677364-B Pharmaceutical compositions comprising anti-191P 4D12 antibody drug conjugates and methods of use thereof 艾更斯司股份有限公司 2024-07-05 CN disclosed
EP-4378482-A2 DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES Seagen Inc. (US) 2024-06-05 EP disclosed
US-20240139275-A1 WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES SEAGEN INC (US) 2024-05-02 US disclosed
US-20240131176-A1 SYNERGISTIC EFFECTS BETWEEN AURISTATIN-BASED ANTIBODY DRUG CONJUGATES AND INHIBITORS OF THE PI3K-AKT MTOR PATHWAY SEAGEN INC (US) 2024-04-25 US disclosed
US-20240043556-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 158P1D7 PROTEINS AGENSYS, INC. (US) 2024-02-08 US disclosed
EP-3545969-B1 DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES SEAGEN INC (US) 2023-12-13 EP disclosed
US-20230346968-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS AGENSYS, INC. (US) 2023-11-02 US disclosed
US-20230270871-A1 MARKERS FOR USE IN METHODS FOR TREATING CANCERS WITH ANTIBODY DRUG CONJUGATES (ADC) AGENSYS, INC. (US) 2023-08-31 US disclosed
CN-116209464-A Markers for use in methods of treating cancer with Antibody Drug Conjugates (ADCs) 艾更斯司股份有限公司 2023-06-02 CN disclosed
EP-4168039-A1 MARKERS FOR USE IN METHODS FOR TREATING CANCERS WITH ANTIBODY DRUG CONJUGATES (ADC) Agensys, Inc. (US) 2023-04-26 EP disclosed
US-20110110936-A1 ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-05-12 US disclosed
WO-2011050242-A1 ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS MILLENNIUM PHARMACEUTICALS, INC. (US) 2011-04-28 WO disclosed
WO-2011038159-A2 DR5 LIGAND DRUG CONJUGATES SEATTLE GENETICS, INC. (US) 2011-03-31 WO disclosed
US-20110070248-A1 DR5 LIGAND DRUG CONJUGATES SEATTLE GENETICS, INC. (US) 2011-03-24 US disclosed
US-20100330107-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS AGENSYS, INC. (US) 2010-12-30 US disclosed
WO-2010111018-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS AGENSYS, INC. (US) 2010-09-30 WO disclosed
US-20100215671-A1 Combination Therapy With Antibody-Drug Conjugates SEAGEN INC. 2010-08-26 US disclosed
EP-2211885-A1 COMBINATION THERAPY WITH ANTIBODY-DRUG CONJUGATES Seattle Genetics, Inc. (US) 2010-08-04 EP disclosed
WO-2010081004-A1 WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES SEATTLE GENETICS, INC. (US) 2010-07-15 WO disclosed
WO-2009048967-A1 COMBINATION THERAPY WITH ANTIBODY-DRUG CONJUGATES SEATTLE GENETICS, INC. (US) 2009-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240131176-A1 SYNERGISTIC EFFECTS BETWEEN AURISTATIN-BASED ANTIBODY DRUG CONJUGATES AND INHIBITORS OF THE PI3K-AKT MTOR PATHWAY MTOR, RICTOR, PIK3R5 ALDH1A1 3563/4885ALOX15 4615/4885HSD17B10 2769/4885
US-20240043556-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 158P1D7 PROTEINS LGALS3BP, PABPC4, PA2G4 ALDH1A1 1052/4885ALOX15 4472/4885HSD17B10 3149/4885
US-20100330107-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS CD2BP2, IGSF11, PA2G4 ALDH1A1 1372/4885ALOX15 4458/4885HSD17B10 1210/4885
US-20110070248-A1 DR5 LIGAND DRUG CONJUGATES TNFRSF1A, TNFSF10, TNFRSF9 ALDH1A1 2427/4885ALOX15 1497/4885HSD17B10 3326/4885
US-20240139275-A1 WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES CD44, PABPC1, CD47 ALDH1A1 639/4885ALOX15 2793/4885HSD17B10 909/4885
US-20100215671-A1 Combination Therapy With Antibody-Drug Conjugates BCL6, BCL3, CD22 ALDH1A1 546/4885ALOX15 4119/4885HSD17B10 1019/4885
US-20110110936-A1 ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS CD2BP2, UACA, COPG2 ALDH1A1 4609/4885ALOX15 4549/4885HSD17B10 4415/4885
US-20230270871-A1 MARKERS FOR USE IN METHODS FOR TREATING CANCERS WITH ANTIBODY DRUG CONJUGATES (ADC) CD44, CD2BP2, EPCAM ALDH1A1 73/4885ALOX15 4270/4885HSD17B10 2939/4885
US-20230346968-A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS IGSF11, CD2BP2, PA2G4 ALDH1A1 801/4885ALOX15 4658/4885HSD17B10 1295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.