Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | DBH | P09172 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.42 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685828 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPTNPC1RAB9A | |
| SCHEMBL8685597 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TDP1MAPTNPC1RAB9A | |
| SCHEMBL8690882 | 0.84 | TDP1 (0.65) | ALDH1A1TDP1MAPTNPC1RAB9A | |
| SCHEMBL2646681 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TDP1MAPTHTTSMN1; SMN2 | |
| SCHEMBL8685734 | 0.80 | ALDH1A1 (0.49) | ALDH1A1TDP1MAPTHTTSMN1; SMN2 | |
| SCHEMBL8685573 | 0.80 | ALDH1A1 (0.71) | ALDH1A1TDP1MAPTNPC1RAB9A | |
| SCHEMBL8690561 | 0.80 | CHRNB2 (0.48) | ALDH1A1TDP1MAPTNPC1RAB9A | |
| SCHEMBL8687046 | 0.79 | PARP1 (0.56) | ALDH1A1TDP1HTTPOLBMEN1 | |
| SCHEMBL8685487 | 0.79 | PARP1 (0.56) | ALDH1A1TDP1HTTPOLBMEN1 | |
| SCHEMBL8811879 | 0.79 | PARP1 (0.43) | ALDH1A1MAPTDBHSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |