Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | HTT | P42858 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685381 | 0.84 | ALDH1A1 (0.56) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL28467331 | 0.82 | ALDH1A1 (0.70) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL28480601 | 0.81 | TDP1 (0.58) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL27707843 | 0.80 | TP53 (0.63) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL31542001 | 0.79 | TDP1 (1.00) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL28527982 | 0.79 | ALDH1A1 (0.70) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL30487286 | 0.79 | ALDH1A1 (1.00) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL30487282 | 0.79 | SMN1; SMN2 (0.72) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL6705979 | 0.79 | SMN1; SMN2 (0.72) | TDP1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL4357272 | 0.79 | ALDH1A1 (1.00) | TDP1ALDH1A1SMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |