Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM2 | P31350 | 8/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.41 |
| ▸ | RRM1 | P23921 | 1/20 | 0.41 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688249 | 0.82 | MAOA (0.57) | RRM2NCOA3RRM1RRM2BCISD1 | |
| SCHEMBL293101 | 0.69 | TOP2A (0.68) | RRM2NCOA3RRM1RRM2BCISD1 | |
| SCHEMBL534248 | 0.69 | TOP2A (0.68) | RRM2NCOA3RRM1RRM2BCISD1 | |
| SCHEMBL8683198 | 0.68 | RRM2 (0.43) | RRM2NCOA3RRM1RRM2BCISD1 | |
| SCHEMBL8683949 | 0.67 | RRM2 (0.44) | RRM2NCOA3RRM1RRM2BCISD1 | |
| SCHEMBL17835748 | 0.65 | RRM2 (0.55) | RRM2NCOA3RRM1RRM2BCISD1 | |
| SCHEMBL17835747 | 0.65 | RRM2 (0.55) | RRM2NCOA3RRM1RRM2BCISD1 | |
| SCHEMBL13826735 | 0.64 | POLB (0.61) | RRM2KDM4EPOLBMAOB | |
| SCHEMBL17835729 | 0.63 | POLB (0.59) | KDM4EPOLBMAOAMAOB | |
| SCHEMBL17835730 | 0.63 | POLB (0.59) | KDM4EPOLBMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721259-A | Method of using 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0570294-B1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | UNIV YALE (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5281715-A | 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0570294-A1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | YALE UNIVERSITY (US) | 1993-11-18 | — | — | EP | disclosed |