Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | DDO | Q99489 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685683 | 0.88 | KDR (0.40) | CHEK1KDRALDH1A1KDM4EHPGD | |
| SCHEMBL8685666 | 0.72 | CDK4 (0.52) | ALDH1A1HPGDNPC1RAB9AMEN1 | |
| SCHEMBL28637736 | 0.72 | RAB9A (0.46) | CHEK1KDRALDH1A1KDM4EHPGD | |
| SCHEMBL78988 | 0.72 | KDR (0.45) | CHEK1KDRALDH1A1KDM4EHPGD | |
| SCHEMBL8478369 | 0.71 | SIRT2 (0.50) | ALDH1A1HPGDNPC1RAB9AMEN1 | |
| SCHEMBL3959785 | 0.71 | KDR (0.44) | CHEK1KDRALDH1A1KDM4EHPGD | |
| SCHEMBL15758299 | 0.69 | MAPT (0.57) | CHEK1KDRALDH1A1KDM4EHPGD | |
| SCHEMBL7857767 | 0.69 | DRD2 (0.50) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL29245492 | 0.67 | TSHR (0.59) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL6477283 | 0.66 | ITK (0.51) | CHEK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843935-A | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5821365-A | COMPOUNDS AS ENZYME INHIBITORS FOR KINASES FORMED BY REACTION OF AMINE WITH ANHYDRIDE GROUP TO FORM INDOLMALEIMIDE MACROCYCLES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5780461-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| US-5739322-A | INHIBITORS OF PROTEIN KINASE C IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-04-14 | — | — | US | disclosed |
| US-5719175-A | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| US-5698578-A | BIS-INDOLEMALEIMIDE MACROCYCLE DERIVATIVES; TREATMENT OF DIABETES | ELI LILLY AND COMPANY (US) | 1997-12-16 | — | — | US | disclosed |
| US-5696108-A | ADMINISERING TO THE MAMMAL BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVE AS ANTIINFLAMMATORY AGENT | ELI LILLY AND COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5674862-A | USING A BIS(INDOLEMALEIMIDE) MACROCYCLE DERIVATIVE | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |