Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 9/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683968 | 0.88 | NAMPT (0.65) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL29952966 | 0.87 | KMT2A (0.69) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL7854890 | 0.85 | CASR (0.63) | CASRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14274121 | 0.84 | CASR (0.67) | CASRRAB9ANPC1MAPTMEN1 | |
| SCHEMBL8870336 | 0.83 | NAMPT (0.52) | CASRRAB9ANPC1MAPTMEN1 | |
| SCHEMBL14274120 | 0.83 | CASR (0.65) | CASRRAB9ANPC1MAPTMEN1 | |
| SCHEMBL8669488 | 0.83 | RAB9A (0.69) | CASRRAB9ANPC1MAPTMEN1 | |
| SCHEMBL8672958 | 0.82 | RAB9A (0.60) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL7610708 | 0.82 | NAMPT (0.47) | CASRRAB9ANPC1MAPTMEN1 | |
| SCHEMBL14274122 | 0.82 | CASR (0.64) | CASRRAB9ANPC1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716936-A | Pyrrolidine derivatives for the treatment of cholecystokinine and gastrine-related disorders | RHONE-POULENC RORER S.A. (FR) | 1998-02-10 | — | — | US | disclosed |
| US-5610144-A | CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-03-11 | — | — | US | disclosed |