Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCND2 | P30279 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8686302 | 0.82 | MAPK8 (0.57) | MAPK8MAPK9CDK4CCND1CCND2 | |
| SCHEMBL8686290 | 0.82 | ALDH1A1 (0.54) | ALDH1A1GAACA5ATSHRNFKB1 | |
| SCHEMBL8682666 | 0.80 | MAPT (0.56) | MAPK8MAPK9CDK4CCND1CCND2 | |
| SCHEMBL153055 | 0.73 | GAA (0.74) | ALDH1A1GAACA5ATSHRNFKB1 | |
| SCHEMBL30049382 | 0.73 | GAA (0.74) | ALDH1A1GAACA5ATSHRNFKB1 | |
| SCHEMBL15244552 | 0.73 | FGFR3 (0.56) | — | |
| SCHEMBL14069852 | 0.72 | MAPT (0.66) | ALDH1A1GAATSHRNFKB1RAB9A | |
| SCHEMBL27952523 | 0.72 | GAA (0.72) | ALDH1A1GAACA5ATSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL2530820 | 0.72 | GAA (0.72) | ALDH1A1GAACA5ATSHRNFKB1 | |
| SCHEMBL3269159 | 0.71 | ABCG2 (0.67) | GAAEGFRFLT3JAK2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719187-A | Compounds having a guanidine structure and pharmaceutical composition containing same | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS) (FR) | 1998-02-17 | — | — | US | disclosed |
| US-5480884-A | Compounds having a guanidine structure | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1996-01-02 | — | — | US | disclosed |
| EP-0572635-A1 | NOVEL COMPOUNDS HAVING A GUANIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME. | CENTRE NAT RECH SCIENT (FR) | 1993-12-08 | — | — | EP | disclosed |
| EP-0572635-A4 | NOVEL COMPOUNDS HAVING A GUANIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME. | CENTRE NAT RECH SCIENT (FR) | 1993-09-17 | — | — | EP | disclosed |
| WO-1993010102-A1 | NOVEL COMPOUNDS HAVING A GUANIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) | 1993-05-27 | — | — | WO | disclosed |