Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | TPMT | P51580 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCND2 | P30279 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8682666 | 0.89 | MAPT (0.56) | MAPK8MAPK9FLT3HDAC3HDAC1 | |
| SCHEMBL8686294 | 0.82 | MAPK8 (0.54) | MAPK8MAPK9FLT3CDK4CCND1 | |
| SCHEMBL3634270 | 0.81 | HDAC3 (0.74) | CA1CA2HDAC3HDAC1HDAC2 | |
| SCHEMBL8686297 | 0.78 | L3MBTL1 (0.55) | CA12CA1CA2CA4CA6 | |
| SCHEMBL5038697 | 0.76 | MAPK13 (0.52) | MAPK8MAPK9MAPTCTSVCTSL | |
| SCHEMBL4489904 | 0.76 | MAPK8 (0.48) | MAPK8MAPK9FLT3HDAC3HDAC1 | |
| SCHEMBL3269159 | 0.74 | ABCG2 (0.67) | FLT3MAPTEGFRNPC1RAB9A | |
| SCHEMBL4485439 | 0.74 | SYK (0.59) | MAPK8MAPK9FLT3HDAC3HDAC1 | |
| SCHEMBL14657966 | 0.73 | MAPK8 (1.00) | MAPK8MAPK9EGFRITK | |
| SCHEMBL670354 | 0.73 | HDAC6 (0.72) | MAPK8HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719187-A | Compounds having a guanidine structure and pharmaceutical composition containing same | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS) (FR) | 1998-02-17 | — | — | US | disclosed |
| US-5480884-A | Compounds having a guanidine structure | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1996-01-02 | — | — | US | disclosed |