Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 4/20 | 0.52 |
| ▸ | HTR1B | P28222 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 4/20 | 0.52 |
| ▸ | NOS1 | P29475 | 4/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8686957 | 0.81 | NOS3 (0.61) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL8097614 | 0.81 | KDM4E (0.58) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL8508491 | 0.78 | KDM4E (0.68) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL8784248 | 0.77 | KDM4E (0.57) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL30877857 | 0.77 | KDM4E (0.67) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL29206549 | 0.77 | KDM4E (0.67) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL1122547 | 0.77 | HTR1D (0.85) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL2926854 | 0.77 | KDM4E (0.67) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL8474262 | 0.76 | KDM4E (0.56) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL7335724 | 0.76 | HTR6 (0.68) | KDM4EATMHTR1DHTR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770742-A | SEROTONIN RECEPTOR SELECTIVITY, MIGRAINES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-23 | — | — | US | claimed |
| WO-1997043281-A1 | THIOPHENE- AND FURAN-TRYPTAMINE DERIVATIVES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-11-20 | — | — | WO | claimed |
| US-5770742-A | SEROTONIN RECEPTOR SELECTIVITY, MIGRAINES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-23 | — | — | US | disclosed |
| WO-1997043281-A1 | THIOPHENE- AND FURAN-TRYPTAMINE DERIVATIVES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-11-20 | — | — | WO | disclosed |