SCHEMBL8686343

SCHEMBL8686343

COc1ccc2c(c1Cl)N(C)c1ccccc1C2C(=S)Oc1ccc(F)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.35
LMNA P02545 3/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
MAPT P10636 2/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 1/20 0.32
NLRP1 Q9C000 1/20 0.32
HIF1A Q16665 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.31
P2RX7 Q99572 1/20 0.31
TSHR P16473 1/20 0.31
HDAC4 P56524 1/20 0.30
HDAC7 Q8WUI4 1/20 0.30
HDAC5 Q9UQL6 1/20 0.30
HSD11B1 P28845 1/20 0.30
GAA P10253 1/20 0.30
DRD2 P14416 1/20 0.30
DRD4 P21917 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8332615 0.83 HDAC4 (0.36) MAPK1LMNASMN1; SMN2MAPTNPC1
SCHEMBL7022484 0.82 HDAC4 (0.43) MAPK1LMNASMN1; SMN2MAPTKMT2A
SCHEMBL7755159 0.81 TP53 (0.37) MAPTKMT2AALDH1A1HDAC4HDAC7
SCHEMBL7025463 0.76 HDAC4 (0.44) SMN1; SMN2MAPTNPC1RAB9AALDH1A1
SCHEMBL5705454 0.75 HDAC4 (0.43) LMNASMN1; SMN2KMT2AHDAC4HDAC7
SCHEMBL29446488 0.75 HDAC4 (0.43) LMNASMN1; SMN2KMT2AHDAC4HDAC7
SCHEMBL8686432 0.74 KMT2A (0.35) MAPK1LMNASMN1; SMN2MAPTNPC1
SCHEMBL5161928 0.72 HDAC4 (0.47) LMNASMN1; SMN2MAPTKMT2AALDH1A1
SCHEMBL8740675 0.72 HDAC4 (0.40) LMNASMN1; SMN2KMT2AALDH1A1HDAC4
SCHEMBL7755709 0.71 HDAC4 (0.44) LMNASMN1; SMN2MAPTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670644-A CHEMILUMINESCENT REACTIONS, PEROXIDASE AND PH FOR IMMUNOASSAY LUMIGEN, INC. (US) 1997-09-23 US claimed
US-5723295-A MULTISTAGE CHEMILUMINESCENT ASSAY WITH PEROXIDASE ENZYME, PH ADJUSTMENT LUMIGEN, INC. (US) 1998-03-03 US disclosed
US-5670644-A CHEMILUMINESCENT REACTIONS, PEROXIDASE AND PH FOR IMMUNOASSAY LUMIGEN, INC. (US) 1997-09-23 US disclosed