SCHEMBL5705454

SCHEMBL5705454

CN1c2ccccc2C(C(=S)Oc2ccc(Cl)cc2)c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
BCHE P06276 1/20 0.39
EGFR P00533 1/20 0.37
SRC P12931 1/20 0.37
LIPE Q05469 3/20 0.37
SLC6A2 P23975 2/20 0.36
SLC6A4 P31645 2/20 0.36
SLC6A3 Q01959 2/20 0.36
LMNA P02545 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
DRD2 P14416 3/20 0.34
DRD4 P21917 3/20 0.34
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
HRH1 P35367 1/20 0.34
ACHE P22303 2/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29446488 1.00 HDAC4 (0.43) HDAC4HDAC7HDAC5BCHEEGFR
SCHEMBL5161928 0.88 HDAC4 (0.47) HDAC4HDAC7HDAC5BCHEEGFR
SCHEMBL7755709 0.87 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7025463 0.87 HDAC4 (0.44) HDAC4HDAC7HDAC5BCHEEGFR
SCHEMBL7022484 0.86 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7755151 0.82 HDAC4 (0.40) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7755731 0.82 HDAC4 (0.42) HDAC4HDAC7HDAC5BCHEEGFR
SCHEMBL7752453 0.80 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7755159 0.77 TP53 (0.37) HDAC4HDAC7HDAC5SLC6A2SLC6A4
Chlorobenzene SCHEMBL28307149 0.77 HDAC4 (0.49) HDAC4HDAC7HDAC5EGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115028580-B Synthesis method of chemiluminescent reagent APS-5 for immunoassay 北京礼为科技有限公司 2024-02-23 CN claimed
CN-115028580-A Method for synthesizing chemiluminescence reagent APS-5 for immunoassay 北京礼为科技有限公司 2022-09-09 CN claimed
CN-114213325-B Preparation method and application of 10-methyl-9, 10-acridine dihydride-9-thiocarboxylic acid-4-chlorophenyl ester 北京富盛嘉华医药科技有限公司 2023-06-23 CN disclosed
CN-109928926-B Improved preparation process of chemical luminescent APS-5 key intermediate 昆明思安生物科技有限公司 2022-12-27 CN disclosed
CN-115028580-A Method for synthesizing chemiluminescence reagent APS-5 for immunoassay 北京礼为科技有限公司 2022-09-09 CN disclosed
CN-114213325-A Preparation method and application of 10-methyl-9, 10-acridan-9-thiocarboxylic acid-4-chlorophenyl ester 北京富盛嘉华医药科技有限公司 2022-03-22 CN disclosed
EP-1054933-B1 CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES LUMIGEN INC (US) 2006-09-06 EP disclosed
US-6635437-B2 Useful in methods for producing light and in assays for phosphatase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs LUMIGEN, INC. 2003-10-21 US disclosed
EP-1054933-A4 CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES LUMIGEN INC (US) 2003-07-09 EP disclosed
EP-0819119-B1 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN INC (US) 2003-04-02 EP disclosed
US-20030023089-A1 Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes AKHAVAN-TAFTI HASHEM (US) 2003-01-30 US disclosed
US-6139782-A A CHEMILUMINESCENT CONTAINING A HETEROCYCLIC RING GROUP AND AN ENOL PHOSPHATE GROUP WHICH REACT WITH OXYGEN UPON REMOVAL OF PHOSPHATE GROUP WITH A PHOSPHATASE ENZYME TO PRODUCE AN ENOLATE WHICH REACTS WITH TO PRODUCE CHEMILUMINOESCENCE LUMIGEN, INC. (US) 2000-10-31 US disclosed
US-6090571-A REACTING PHOSPHATASE WITH NITROGEN-CONTAINING HETEROCYCLIC RING SYSTEM HAVING AN ENOL PHOSPHATE GROUP, DETECTING THE CHEMILUMINESCENCE, AND RELATING TO AMOUNT OF ANALYTE LUMIGEN, INC. (US) 2000-07-18 US disclosed
US-6045727-A NITROGEN CONTAINING HETEROCYCLIC RING SYSTEM BEARING AN EXOCYCLIC CARBON-CARBON DOUBLE BOND. THE DOUBLE BOND IS FURTHER SUBSTITUTED AT THE DISTAL CARBON WITH A PHOSPHATE GROUP AND AN OXYGEN OR SULFUR ATOM-CONTAINING GROUP. LUMIGEN, INC. (US) 2000-04-04 US disclosed
WO-1999040161-A1 CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES LUMIGEN, INC. (US) 1999-08-12 WO disclosed
EP-0819119-A4 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN INC (US) 1999-04-14 EP disclosed
US-5840963-A HALOGEN-SUBSTITUTED HYDROQUINONES HAVING ONE HYDROXY GROUP PROTECTED BY PHOSPHATE GROUP LUMIGEN, INC. (US) 1998-11-24 US disclosed
US-5772926-A ANALYSIS OF HYDROLYTIC ENZYMES AND ENZYME INHIBITORS; LABELED BINDING PAIRS LUMIGEN, INC. (US) 1998-06-30 US disclosed
EP-0819119-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN, INC. (US) 1998-01-21 EP disclosed
WO-1997026245-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN, INC. (US) 1997-07-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030023089-A1 Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes PPP6C, PPP4C, PPP2CA HDAC4 4216/4885HDAC7 4375/4885HDAC5 3776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.