SCHEMBL5161928

SCHEMBL5161928

CN1c2ccccc2C(C(=S)Oc2ccccc2)c2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
EGFR P00533 2/20 0.43
SRC P12931 1/20 0.43
HTR2A P28223 2/20 0.37
HTR2C P28335 2/20 0.37
HRH1 P35367 2/20 0.37
ACHE P22303 4/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
GAA P10253 2/20 0.36
LMNA P02545 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ADRA2A P08913 1/20 0.36
ADRA2B P18089 1/20 0.36
ADRA2C P18825 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7755709 0.89 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7025463 0.89 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL5705454 0.88 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL29446488 0.88 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7022484 0.88 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7755151 0.84 HDAC4 (0.40) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7755731 0.84 HDAC4 (0.42) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7024113 0.83 IDO1 (0.36) HDAC4HDAC7HDAC5MEN1KMT2A
SCHEMBL30132855 0.81 HDAC4 (0.55) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL2218308 0.81 HDAC4 (0.55) HDAC4HDAC7HDAC5EGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0755457-B1 Novel Aryl-N-Alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection LUMIGEN INC (US) 2001-02-21 EP claimed
EP-0755457-A4 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN INC (US) 1997-07-16 EP claimed
EP-0755457-A1 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN, INC. (US) 1997-01-29 EP claimed
US-5523212-A OXIDATION WITH PEROXIDE AND PEROXIDASE TO EXCITED ACRIDONE DERIVATIVE; DETECTING PROTEINS, HAPTENS, ANTIBODIES, ENZYMES LUMIGEN, INC. (US) 1996-06-04 US claimed
WO-1995028495-A1 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN, INC. (US) 1995-10-26 WO claimed
EP-1029016-B1 NOVEL CHEMILUMINESCENT LABELING COMPOUNDS LUMIGEN INC (US) 2007-03-07 EP disclosed
EP-1054933-B1 CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES LUMIGEN INC (US) 2006-09-06 EP disclosed
EP-1005649-B1 NON-ENZYMATIC METHODS OF GENERATING CHEMILUMINESCENCE FROM ACRIDAN ALKENES LUMIGEN INC (US) 2006-04-12 EP disclosed
US-6891057-B2 Compounds for generating chemiluminescence with a peroxidase LUMIGEN, INC. (US) 2005-05-10 US disclosed
EP-1019525-B1 CHEMILUMINESCENCE COMPOSITIONS AND METHODS LUMIGEN INC (US) 2004-10-20 EP disclosed
US-20040144948-A1 Novel compounds for generating chemiluminescence with a peroxidase AKHAVAN-TAFTI HASHEM (US) 2004-07-29 US disclosed
EP-1015461-B1 NOVEL COMPOUNDS FOR GENERATING CHEMILUMINESCENCE WITH A PEROXIDASE LUMIGEN INC (US) 2004-05-12 EP disclosed
US-5840963-A HALOGEN-SUBSTITUTED HYDROQUINONES HAVING ONE HYDROXY GROUP PROTECTED BY PHOSPHATE GROUP LUMIGEN, INC. (US) 1998-11-24 US disclosed
US-5772926-A ANALYSIS OF HYDROLYTIC ENZYMES AND ENZYME INHIBITORS; LABELED BINDING PAIRS LUMIGEN, INC. (US) 1998-06-30 US disclosed
EP-0819119-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN, INC. (US) 1998-01-21 EP disclosed
WO-1997026245-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN, INC. (US) 1997-07-24 WO disclosed
EP-0755457-A4 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN INC (US) 1997-07-16 EP disclosed
EP-0755457-A1 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN, INC. (US) 1997-01-29 EP disclosed
US-5523212-A OXIDATION WITH PEROXIDE AND PEROXIDASE TO EXCITED ACRIDONE DERIVATIVE; DETECTING PROTEINS, HAPTENS, ANTIBODIES, ENZYMES LUMIGEN, INC. (US) 1996-06-04 US disclosed
WO-1995028495-A1 NOVEL ARYL-N-ALKYLACRIDANTHIOCARBOXYLATE DERIVATIVES USEFUL FOR CHEMILUMINESCENT DETECTION LUMIGEN, INC. (US) 1995-10-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040144948-A1 Novel compounds for generating chemiluminescence with a peroxidase LPO, MPO, GPX4 HDAC4 4162/4885HDAC7 4561/4885HDAC5 4270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.