Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | HPGD | P15428 | 8/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504338 | 0.88 | DRD2 (0.48) | DRD2HTR2AHRH1PPARGPPARA | |
| SCHEMBL13633777 | 0.83 | DRD2 (0.49) | DRD2HTR2AHRH1PPARGPPARA | |
| SCHEMBL504421 | 0.81 | DRD2 (0.48) | DRD2HTR2AHRH1PPARGPPARA | |
| SCHEMBL8691847 | 0.78 | DRD2 (0.46) | DRD2HTR2AHRH1PPARGPPARA | |
| SCHEMBL979145 | 0.76 | KDM4E (0.65) | PPARGPPARAKDM4EHPGDNPC1 | |
| SCHEMBL8688814 | 0.76 | KDM4E (0.47) | DRD2HTR2AHRH1PPARGPPARA | |
| SCHEMBL8859183 | 0.76 | PPARG (0.52) | PPARGPPARAALDH1A1KDM4EHPGD | |
| SCHEMBL3530493 | 0.76 | RAB9A (0.53) | PPARGPPARAALDH1A1KDM4EHPGD | |
| SCHEMBL8132645 | 0.75 | PPARG (0.48) | PPARGPPARA | |
| SCHEMBL4034983 | 0.75 | KDR (0.53) | PPARGPPARAALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763467-A | Hypoglycemic hydroxyurea derivatives | PFIZER INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5646168-A | ANTICHOLESTEROL AGENTS | GOLDSTEIN STEVEN WAYNE (US) | 1997-07-08 | — | — | US | disclosed |
| US-5463070-A | Antidiabetic and anticholesterol agents | PFIZER INC. (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544696-B1 | HYPOGLYCEMIC HYDROXYUREA DERIVATIVES | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5334604-A | Administering to mammals to lower glucose and/or cholesterol in the blood | PFIZER INC. (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0544696-A1 | HYPOGLYCEMIC HYDROXYUREA DERIVATIVES. | PFIZER HOSPITAL PROD (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003425-A1 | HYPOGLYCEMIC HYDROXYUREA DERIVATIVES | PFIZER INC. (US) | 1992-03-05 | — | — | WO | disclosed |