Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.61 |
| ▸ | PPARG | P37231 | 10/20 | 0.58 |
| ▸ | PPARA | Q07869 | 9/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | PPARD | Q03181 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4888378 | 0.97 | RAB9A (0.62) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL3376008 | 0.91 | KDM4E (0.59) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL5022312 | 0.90 | KDM4E (0.61) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL3530493 | 0.90 | RAB9A (0.53) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL5204314 | 0.90 | KDM4E (0.54) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL5858351 | 0.89 | PPARG (0.60) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL5014287 | 0.89 | KDM4E (0.52) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL30193546 | 0.89 | KDM4E (0.52) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL3532628 | 0.89 | KDM1A (0.57) | KDM4EHRH3PPARGPPARANPC1 | |
| SCHEMBL5857599 | 0.88 | PPARG (0.62) | KDM4EHRH3PPARGPPARANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 397 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | CHENG PETER T | 2007-01-18 | — | — | US | claimed |
| US-20060178405-A1 | Benzopyran compounds, process for preparing the same and their use | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2006-08-10 | — | — | US | claimed |
| CN-1244573-C | Benzofuran category compound, its preparing method and usage | SHANGHAI MEDICATION INST CHINE (CN) | 2006-03-08 | — | — | CN | claimed |
| CN-1231482-C | Process for preparing thiazolidinedione derivatives and intermediates | HOFFMANN LA ROCHE (CH) | 2005-12-14 | — | — | CN | claimed |
| EP-1598345-A1 | BENZOPYRAN COMPOUNDS, PROCESS FOR PREPARING THE SAME AND THEIR USE | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2005-11-23 | — | — | EP | claimed |
| EP-1282619-B1 | PROCESSES FOR THE PREPARATION OF THIAZOLIDINEDIONE DERIVATIVES AND INTERMEDIATES | HOFFMANN LA ROCHE (CH) | 2005-06-22 | — | — | EP | claimed |
| US-20040024222-A1 | Process for the preparation of thiazolidinedione derivatives | SCALONE MICHELANGELO (CH) | 2004-02-05 | — | — | US | claimed |
| CN-1445222-A | Benzofuran category compound, its preparing method and usage | SHANGHAI MEDICATION INST CHINE (CN) | 2003-10-01 | — | — | CN | claimed |
| CN-1422267-A | Processes for the preparation of thiazolidinedione derivatives and intermediates | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | CN | claimed |
| US-20030092916-A1 | Process for the preparation of thiazolidinedione derivatives | SCALONE MICHELANGELO (CH) | 2003-05-15 | — | — | US | claimed |
| EP-1282619-A1 | PROCESSES FOR THE PREPARATION OF THIAZOLIDINEDIONE DERIVATIVES AND INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-12 | — | — | EP | claimed |
| US-20010049445-A1 | Process for the preparation of thiazolidinedione derivatives | HOFFMANN-LA ROCHE INC. | 2001-12-06 | — | — | US | claimed |
| WO-2001079202-A1 | PROCESSES FOR THE PREPARATION OF THIAZOLIDINEDIONE DERIVATIVES AND INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-25 | — | — | WO | claimed |
| US-9181181-B2 | 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease | ALBIREO AB (SE) | 2015-11-10 | — | — | US | disclosed |
| WO-2015028960-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AS GPR AGONISTS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2015-03-05 | — | — | WO | disclosed |
| EP-2102198-B1 | SULFONYL-PHENYL-2H-[1,2,4]OXODIAZOL-5-ONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2015-02-25 | — | — | EP | disclosed |
| CN-1003445-B | thiazolidinedione derivatives, their preparation and use | 武田药品工业株式会社 | 1989-03-01 | — | — | CN | disclosed |
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| CN-85107870-A | The preparation method of thiazolidine diketone derivative and purposes | — | 1986-07-16 | — | — | CN | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092916-A1 | Process for the preparation of thiazolidinedione derivatives | SLC5A2, CYP4B1, CYP4F3 | KDM4E 1998/4885HRH3 4051/4885PPARG 80/4885 |
| US-20010049445-A1 | Process for the preparation of thiazolidinedione derivatives | SLC5A2, CYP4B1, CYP4F3 | KDM4E 1998/4885HRH3 4051/4885PPARG 80/4885 |
| US-20060178405-A1 | Benzopyran compounds, process for preparing the same and their use | SLC5A2, CYP2D6, IAPP | KDM4E 1908/4885HRH3 802/4885PPARG 670/4885 |
| US-20040024222-A1 | Process for the preparation of thiazolidinedione derivatives | SLC5A2, CYP4B1, CYP4F3 | KDM4E 1998/4885HRH3 4051/4885PPARG 80/4885 |
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | GPR119, LIPC, ACACA | KDM4E 2164/4885HRH3 911/4885PPARG 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.