Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688820 | 0.90 | PTGS2 (0.56) | PTGS2PTGS1PDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8689466 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1PDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8691654 | 0.89 | PTGS2 (0.45) | PTGS2PTGS1PDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8641068 | 0.85 | PTGS2 (0.53) | PTGS2PTGS1PDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8694101 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8636729 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8635943 | 0.83 | PTGS2 (0.41) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8640455 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8691414 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8641628 | 0.83 | HPGD (0.45) | PTGS2PTGS1PDPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |