Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.44 |
| ▸ | F10 | P00742 | 8/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | PROC | P04070 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688899 | 0.89 | PTGS2 (0.44) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8689185 | 0.88 | PTGS2 (0.57) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8688926 | 0.87 | PTGS2 (0.42) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8727373 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8636729 | 0.85 | PTGS2 (0.43) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8652506 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8635943 | 0.84 | PTGS2 (0.41) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8688501 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1KIF11PDPK1RXRA | |
| SCHEMBL8640455 | 0.84 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL8691414 | 0.84 | PTGS2 (0.56) | PTGS2PTGS1F10PDPK1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |