Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8692558 | 0.90 | PTGS2 (0.41) | MAPTGAAALDH1A1PTGS2POLB | |
| SCHEMBL8688419 | 0.89 | MAPT (0.45) | MAPTKMT2AGAAALDH1A1NPSR1 | |
| SCHEMBL8639075 | 0.88 | PTGS2 (0.41) | LMNAMAPTGAAALDH1A1NPSR1 | |
| SCHEMBL8640282 | 0.87 | PTGS1 (0.53) | LMNAALDH1A1NPSR1HTTPTGS2 | |
| SCHEMBL8689174 | 0.86 | ALDH1A1 (0.45) | LMNAMAPTKMT2AGAAALDH1A1 | |
| SCHEMBL8692069 | 0.82 | PTGS2 (0.56) | LMNAMAPTKMT2AGAAALDH1A1 | |
| SCHEMBL7868758 | 0.78 | PTGS2 (0.53) | MAPTNPSR1CYP3A4CYP2C9PTGS2 | |
| SCHEMBL8693427 | 0.77 | HTT (0.41) | LMNAMAPTKMT2AGAAALDH1A1 | |
| SCHEMBL8693415 | 0.77 | PTGS2 (0.47) | MAPTKMT2AGAAALDH1A1PTGS2 | |
| SCHEMBL8689478 | 0.77 | PTGS2 (0.53) | MAPTGAAALDH1A1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |