Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | FAP | Q12884 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879474 | 0.82 | ITGB3 (0.48) | DPP4HRH2HRH1FAPDPP8 | |
| SCHEMBL8690140 | 0.78 | OPRD1 (0.45) | DPP4HRH2HRH1FAPDPP8 | |
| SCHEMBL8692677 | 0.77 | HRH2 (0.43) | DPP4HRH2HRH1DPP7OPRK1 | |
| SCHEMBL8881323 | 0.76 | DPP4 (0.55) | DPP4HRH2HRH1FAPDPP8 | |
| SCHEMBL8884985 | 0.76 | KMT2A (0.47) | HRH2HRH1 | |
| SCHEMBL4925083 | 0.75 | HDAC3 (0.48) | DPP4HRH2HRH1FAPDPP8 | |
| SCHEMBL4925087 | 0.75 | HDAC3 (0.48) | DPP4HRH2HRH1FAPDPP8 | |
| SCHEMBL4086464 | 0.72 | DPP4 (0.57) | DPP4HRH2HRH1FAPDPP8 | |
| SCHEMBL6162780 | 0.71 | DPP7 (0.60) | DPP4HRH2HRH1FAPDPP8 | |
| SCHEMBL6162776 | 0.71 | DPP7 (0.60) | DPP4HRH2HRH1FAPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747522-A | ANTICOAGULANTS; ANTIINFLAMMATORY AGENTS; ANTITUMOR AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1998-05-05 | — | — | US | disclosed |
| US-5670515-A | TREATMENT OF THROMBOSIS, STROKE, CARDIAC INFARCT, INFLAMMATION, AND ARTERIOSCLEROSIS; ANTITUMOR AGENTS, WOUND HEALING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-23 | — | — | US | disclosed |