Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CDC42 | P60953 | 1/20 | 0.51 |
| ▸ | RAC1 | P63000 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328574 | 0.73 | TDP1 (0.51) | PTGS2TSHRCYP1A2MEN1KMT2A | |
| SCHEMBL9288960 | 0.73 | PTGS2 (0.68) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL23040664 | 0.72 | KDM4E (0.53) | PTGS2TSHRCYP1A2MEN1KMT2A | |
| SCHEMBL23040663 | 0.72 | KDM4E (0.53) | PTGS2TSHRCYP1A2MEN1KMT2A | |
| SCHEMBL23318970 | 0.72 | MAPT (0.46) | PTGS2TSHRCYP1A2MEN1KMT2A | |
| Naproxen SCHEMBL11721059 | 0.71 | AKR1C3 (0.91) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL5828705 | 0.70 | AOC3 (0.50) | PTGS2TSHRCYP1A2MEN1KMT2A | |
| SCHEMBL38651836 | 0.70 | AKR1C3 (0.58) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL60543 | 0.70 | AKR1C3 (0.58) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL15116646 | 0.69 | PTGS2 (0.81) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811438-A | USEFUL FOR PREVENTING OR ALLEVIATING TISSUE EDEMA, CONJUNCTIVA SWELLING AND CONGESTION OR CORNEAL HAZE | ALCON LABORATORIES, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0799219-A2 | ESTERS AND AMIDES OF NON-STEROIDAL ANTI-INFLAMMATORY CARBOXYLIC ACIDS WHICH MAY BE USED AS ANTI-OXIDANTS, 5-LIPOXYGENASE INHIBITORS AND NON-STEROIDAL ANTI-INFLAMMATORY PRODUCTS | ALCON LABORATORIES, INC. (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5643943-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS FOR VASCULAR INFLAMMATION | ALCON LABORATORIES, INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5607966-A | BENZOFURAN OR BENZOPYRAN DERIVATIVES | ALCON LABORATORIES, INC. (US) | 1997-03-04 | — | — | US | disclosed |
| WO-1996020187-A2 | ESTERS AND AMIDES OF NON-STEROIDAL ANTI-INFLAMMATORY CARBOXYLIC ACIDS WHICH MAY BE USED AS ANTI-OXIDANTS, 5-LIPOXYGENASE INHIBITORS AND NON-STEROIDAL ANTI-INFLAMMATORY PRODUCTS | ALCON LABORATORIES, INC. (US) | 1996-07-04 | — | — | WO | disclosed |