Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693592 | 0.94 | HTT (0.42) | HTTALDH1A1SMN1; SMN2SMAD3APAF1 | |
| SCHEMBL8691735 | 0.84 | SMAD3 (0.40) | HTTALDH1A1SMN1; SMN2SMAD3APAF1 | |
| SCHEMBL8691277 | 0.82 | ALDH1A1 (0.47) | HTTALDH1A1SMN1; SMN2ALOX5PDE3B | |
| SCHEMBL8693020 | 0.82 | ALDH1A1 (0.47) | HTTALDH1A1SMN1; SMN2ALOX5PDE3B | |
| SCHEMBL8690895 | 0.81 | HTT (0.42) | HTTALDH1A1SMN1; SMN2ALOX5PDE3B | |
| SCHEMBL9060804 | 0.81 | LTB4R2 (0.44) | — | |
| SCHEMBL8690228 | 0.80 | ALDH1A1 (0.41) | HTTALDH1A1SMN1; SMN2SMAD3APAF1 | |
| SCHEMBL8694595 | 0.80 | — | — | |
| SCHEMBL8692878 | 0.77 | HTT (0.43) | HTTALDH1A1SMN1; SMN2ALOX5PDE3B | |
| SCHEMBL8695084 | 0.75 | EGFR (0.44) | HTTALDH1A1SMN1; SMN2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827863-A | Pyrazole derivatives as angiotensin II antagonists | J. URIACH & CIA, S.A. (ES) | 1998-10-27 | — | — | US | disclosed |
| EP-0721454-A1 | NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST | J. URIACH & CIA. S.A. (ES) | 1996-07-17 | — | — | EP | disclosed |