Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.76 |
| ▸ | HTT | P42858 | 6/20 | 0.76 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29071609 | 0.90 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL4357272 | 0.86 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL30487286 | 0.86 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL15503856 | 0.85 | SMN1; SMN2 (1.00) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL8690446 | 0.81 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL22001276 | 0.80 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL30487284 | 0.80 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL29071626 | 0.80 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL8685876 | 0.80 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2HTTLMNATDP1 | |
| SCHEMBL8812821 | 0.78 | PARP1 (0.74) | ALDH1A1SMN1; SMN2HTTLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |